ARPC2

Actin-related protein 2/3 complex subunit 2 is a protein that in humans is encoded by the ARPC2 gene.^[5][6][7]

ARPC2
Identifiers
Aliases	ARPC2, ARC34, PNAS-139, p34-Arc, PRO2446, actin related protein 2/3 complex subunit 2
External IDs	OMIM: 604224; MGI: 1923959; HomoloGene: 4187; GeneCards: ARPC2; OMA:ARPC2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 218,217,141 bp[1] End 218,254,356 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 38.49 cM|1 C3 Start 74,275,243 bp[2] End 74,307,368 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of sigmoid colon granulocyte mucosa of pharynx skin of hip trabecular bone oral cavity monocyte blood vulva appendix Top expressed in saccule Ileal epithelium otic placode otic vesicle corneal stroma tibiofemoral joint gastrula stroma of bone marrow granulocyte mesenteric lymph nodes More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin filament binding structural constituent of cytoskeleton protein binding actin binding Cellular component cytosol endosome cell projection muscle cell projection membrane focal adhesion plasma membrane arp2/3 protein complex synapse cell junction cell leading edge actin cytoskeleton neuron projection extracellular exosome cytoskeleton cytoplasm nucleus lamellipodium site of double-strand break glutamatergic synapse Biological process positive regulation of actin filament polymerization Fc-gamma receptor signaling pathway involved in phagocytosis ephrin receptor signaling pathway regulation of actin filament polymerization positive regulation of substrate adhesion-dependent cell spreading Arp2/3 complex-mediated actin nucleation positive regulation of lamellipodium assembly membrane organization actin filament polymerization actin polymerization-dependent cell motility Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10109 76709 Ensembl ENSG00000163466 ENSMUSG00000006304 UniProt O15144 Q9CVB6 RefSeq (mRNA) NM_005731 NM_152862 NM_029711 NM_001357387 RefSeq (protein) NP_005722 NP_690601 NP_083987 NP_001344316 Location (UCSC) Chr 2: 218.22 – 218.25 Mb Chr 1: 74.28 – 74.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined.^[7]

Interactions

ARPC2 has been shown to interact with Cortactin.^[8]