ARPC5

Actin-related protein 2/3 complex subunit 5 is a protein that in humans is encoded by the ARPC5 gene.^[5][6][7]

ARPC5
Identifiers
Aliases	ARPC5, ARC16, dJ127C7.3, p16-Arc, actin related protein 2/3 complex subunit 5
External IDs	OMIM: 604227; MGI: 1915021; HomoloGene: 4176; GeneCards: ARPC5; OMA:ARPC5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.3 Start 183,620,846 bp[1] End 183,635,783 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 G3 Start 152,642,293 bp[2] End 152,651,348 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte germinal epithelium lower lobe of lung blood superficial temporal artery appendix trabecular bone granulocyte lymph node placenta Top expressed in granulocyte ileum spleen thymus stomach ganglionic eminence jejunum neural tube Mesencephalon placenta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin filament binding structural constituent of cytoskeleton protein binding actin binding Cellular component cytoplasm cytosol cell projection focal adhesion arp2/3 protein complex actin cytoskeleton extracellular exosome cytoskeleton neuron projection extracellular region endosome growth cone secretory granule lumen ficolin-1-rich granule lumen lamellipodium nucleus site of double-strand break Biological process Fc-gamma receptor signaling pathway involved in phagocytosis ephrin receptor signaling pathway regulation of actin filament polymerization Arp2/3 complex-mediated actin nucleation cell migration actin cytoskeleton organization actin filament network formation orbitofrontal cortex development lamellipodium organization smooth muscle cell migration maintenance of cell polarity neutrophil degranulation membrane organization microtubule organizing center localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10092 67771 Ensembl ENSG00000162704 ENSMUSG00000008475 UniProt O15511 Q9CPW4 RefSeq (mRNA) NM_005717 NM_001270439 NM_026369 RefSeq (protein) NP_001257368 NP_005708 NP_080645 Location (UCSC) Chr 1: 183.62 – 183.64 Mb Chr 1: 152.64 – 152.65 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined.^[7]

Interactions

ARPC5 has been shown to interact with ARPC4.^[8][9]