ART4

Ecto-ADP-ribosyltransferase 4 is an enzyme that in humans is encoded by the ART4 gene.^[5][6] ART4 has also been designated as CD297 (cluster of differentiation 297).

ART4
Identifiers
Aliases	ART4, ARTC4, CD297, DO, DOK1, ADP-ribosyltransferase 4 (Dombrock blood group), DO/ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)
External IDs	OMIM: 110600; MGI: 1202710; HomoloGene: 10883; GeneCards: ART4; OMA:ART4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p12.3 Start 14,825,569 bp[1] End 14,843,526 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 G1|6 66.72 cM Start 136,825,449 bp[2] End 136,834,731 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver right lobe of liver right coronary artery right auricle of heart thoracic aorta ascending aorta gallbladder Descending thoracic aorta left coronary artery trabecular bone Top expressed in fetal liver hematopoietic progenitor cell interventricular septum lacrimal gland lumbar spinal ganglion right lobe of liver embryo myocardium of ventricle thymus blastocyst lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity NAD+-protein-arginine ADP-ribosyltransferase activity glycosyltransferase activity NAD+ ADP-ribosyltransferase activity Cellular component anchored component of membrane membrane extracellular region plasma membrane Biological process protein ADP-ribosylation arginine metabolic process peptidyl-arginine ADP-ribosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 420 109978 Ensembl ENSG00000111339 ENSMUSG00000030217 UniProt Q93070 Q9CRA0 RefSeq (mRNA) NM_021071 NM_001354646 NM_026639 RefSeq (protein) NP_066549 NP_001341575 NP_080915 Location (UCSC) Chr 12: 14.83 – 14.84 Mb Chr 6: 136.83 – 136.83 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinositol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.^[6]

Blood group antigens

Several antigens have been recognised in this family. These are DO*A, DO*JO1, DO*A-WL, DO*DOYA, DO*B, DO*B-WL, DO*B-SH-Q149K, DO*B-(WL)-I175N, DO*HY1, DO*HY2 and DO*DOMR.