ASAH2B

Neutral ceramidase B also known as non-lysosomal ceramidase B or N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B or ASAH2B is a ceramidase enzyme which in humans is encoded by the ASAH2B gene.^[3][4]

ASAH2B
Identifiers
Aliases	ASAH2B, ASAH2L, bA449O16.3, bA98I6.3, N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B, ASAH2C, N-acylsphingosine amidohydrolase 2B
External IDs	GeneCards: ASAH2B; OMA:ASAH2B - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q11.23 Start 50,739,318 bp[1] End 50,816,495 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum gonad islet of Langerhans ganglionic eminence testicle superior frontal gyrus liver primary visual cortex rectum ventricular zone n/a More reference expression data BioGPS n/a
Gene ontology Molecular function N-acylsphingosine amidohydrolase activity Cellular component extracellular region Biological process long-chain fatty acid biosynthetic process sphingosine biosynthetic process ceramide catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 653308 n/a Ensembl ENSG00000204147 n/a UniProt P0C7U1 n/a RefSeq (mRNA) NM_001079516 NM_001321957 NM_001321958 NM_001321959 NM_001321960 n/a RefSeq (protein) NP_001072984 NP_001308886 NP_001308887 NP_001308888 NP_001308889 n/a Location (UCSC) Chr 10: 50.74 – 50.82 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Clinical significance

ASAH2B shows reduced expression with increasing age and further reduction in late onset Alzheimer's disease patients.^[3]