ASAHL

N-acylethanolamine-hydrolyzing acid amidase is an enzyme that in humans is encoded by the NAAA gene.^[5][6][7]

NAAA
Identifiers
Aliases	NAAA, ASAHL, PLT, N-acylethanolamine acid amidase
External IDs	OMIM: 607469; MGI: 1914361; HomoloGene: 8686; GeneCards: NAAA; OMA:NAAA - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.1 Start 75,913,660 bp[1] End 75,941,013 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E2 Start 92,405,518 bp[2] End 92,426,029 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte rectum mucosa of transverse colon spleen mucosa of sigmoid colon blood lymph node minor salivary glands olfactory zone of nasal mucosa Top expressed in choroidal fissure tail of embryo lip yolk sac Epithelium of choroid plexus lumbar spinal ganglion granulocyte white adipose tissue spleen mesenteric lymph nodes More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription factor binding hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds fatty acid amide hydrolase activity Cellular component cytoplasm lysosome extracellular exosome lysosomal lumen presynapse extrinsic component of membrane membrane Biological process lipid metabolism neurotransmitter secretion biological process fatty acid metabolic process N-acylethanolamine metabolic process lipid catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27163 67111 Ensembl ENSG00000138744 ENSMUSG00000029413 UniProt Q02083 Q9D7V9 RefSeq (mRNA) NM_001042402 NM_014435 NM_001363719 NM_001163687 NM_025972 RefSeq (protein) NP_001035861 NP_055250 NP_001350648 NP_001157159 NP_080248 Location (UCSC) Chr 4: 75.91 – 75.94 Mb Chr 5: 92.41 – 92.43 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene.^[7]