ASB6

Ankyrin repeat and SOCS box protein 6 is a protein that in humans is encoded by the ASB6 gene.^[5]

ASB6
Identifiers
Aliases	ASB6, ankyrin repeat and SOCS box containing 6
External IDs	OMIM: 615051; MGI: 1919573; HomoloGene: 9895; GeneCards: ASB6; OMA:ASB6 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.11 Start 129,634,604 bp[1] End 129,642,169 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 30,713,109 bp[2] End 30,720,345 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte right frontal lobe gastric mucosa right hemisphere of cerebellum prefrontal cortex left adrenal cortex middle temporal gyrus right adrenal cortex anterior cingulate cortex skin of leg Top expressed in fetal liver hematopoietic progenitor cell granulocyte yolk sac lip epiblast right kidney submandibular gland neural layer of retina embryo ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm cytosol Biological process intracellular signal transduction protein ubiquitination post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140459 72323 Ensembl ENSG00000148331 ENSMUSG00000039483 UniProt Q9NWX5 Q91ZU1 RefSeq (mRNA) NM_177999 NM_001202403 NM_017873 NM_133346 RefSeq (protein) NP_001189332 NP_060343 NP_821066 NP_579924 Location (UCSC) Chr 9: 129.63 – 129.64 Mb Chr 2: 30.71 – 30.72 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases.^[5]