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ATF6

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

ATF6
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Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene[5][6][7] and is involved in the unfolded protein response.

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Function

ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[8] Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.

See also

Interactions

ATF6 has been shown to interact with YY1[9] and Serum response factor.[6]

References

Further reading

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