Top Qs
Timeline
Chat
Perspective
ATF6
Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
Remove ads
Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene[5][6][7] and is involved in the unfolded protein response.
Remove ads
Function
ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[8] Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.
See also
Interactions
ATF6 has been shown to interact with YY1[9] and Serum response factor.[6]
References
Further reading
External links
Wikiwand - on
Seamless Wikipedia browsing. On steroids.
Remove ads