ATF6

Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene^[5][6][7] and is involved in the unfolded protein response.

ATF6
Identifiers
Aliases	ATF6, ATF6A, ACHM7, activating transcription factor 6
External IDs	OMIM: 605537; MGI: 1926157; HomoloGene: 32015; GeneCards: ATF6; OMA:ATF6 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,766,298 bp[1] End 161,977,574 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 76.96 cM Start 170,532,243 bp[2] End 170,695,340 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis skin of hip skin of thigh retinal pigment epithelium tail of epididymis synovial joint caput epididymis seminal vesicula saphenous vein endothelial cell Top expressed in myocardium of ventricle lacrimal gland submandibular gland cardiac muscles cardiac muscle tissue of left ventricle right ventricle seminal vesicula secondary oocyte stroma of bone marrow aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity transcription coactivator activity transcription cis-regulatory region binding protein binding identical protein binding protein heterodimerization activity ubiquitin protein ligase binding cAMP response element binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component integral component of membrane Golgi apparatus nuclear envelope membrane endoplasmic reticulum membrane Golgi membrane nucleoplasm integral component of endoplasmic reticulum membrane endoplasmic reticulum nucleus cytosol Biological process eye development regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress regulation of transcription by RNA polymerase II transcription, DNA-templated endoplasmic reticulum unfolded protein response ATF6-mediated unfolded protein response response to unfolded protein protein folding signal transduction visual perception positive regulation of apoptotic process transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of ATF6-mediated unfolded protein response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22926 226641 Ensembl ENSG00000118217 ENSMUSG00000026663 UniProt P18850 F6VAN0 RefSeq (mRNA) NM_007348 NM_001081304 RefSeq (protein) NP_031374 NP_001074773 Location (UCSC) Chr 1: 161.77 – 161.98 Mb Chr 1: 170.53 – 170.7 Mb PubMed search [3] [4]
Wikidata
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Function

ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.^[8] Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.

See also

• Activating transcription factor

Interactions

ATF6 has been shown to interact with YY1^[9] and Serum response factor.^[6]