ATF7IP

Activating transcription factor 7-interacting protein 1 is a protein that in humans is encoded by the ATF7IP gene.^[5][6][7]

ATF7IP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RPQ
Identifiers
Aliases	ATF7IP, AM, ATF-IP, MCAF, MCAF1, p621, activating transcription factor 7 interacting protein
External IDs	OMIM: 613644; MGI: 1858965; HomoloGene: 10051; GeneCards: ATF7IP; OMA:ATF7IP - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.1 Start 14,365,632 bp[1] End 14,502,935 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G1 Start 136,506,167 bp[2] End 136,610,862 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell cardia nipple tendon of biceps brachii renal medulla visceral pleura pylorus ventral tegmental area superior surface of tongue trigeminal ganglion Top expressed in zygote genital tubercle tail of embryo trigeminal ganglion interventricular septum lymph node mesenteric lymph nodes lobe of cerebellum cerebellar vermis secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase activity protein binding transcription corepressor activity Cellular component nucleus transcription regulator complex nucleoplasm cytosol nuclear body Biological process positive regulation of transcription, DNA-templated DNA methylation regulation of RNA polymerase II transcription preinitiation complex assembly viral process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of protein stability protein stabilization positive regulation of DNA methylation-dependent heterochromatin assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55729 54343 Ensembl ENSG00000171681 ENSMUSG00000030213 UniProt Q6VMQ6 Q7TT18 RefSeq (mRNA) NM_001286514 NM_001286515 NM_018179 NM_181352 NM_019426 RefSeq (protein) NP_001273443 NP_001273444 NP_060649 NP_851997 NP_060649.3 NP_062299 NP_001375123 NP_001375124 NP_001375125 NP_001375126 Location (UCSC) Chr 12: 14.37 – 14.5 Mb Chr 6: 136.51 – 136.61 Mb PubMed search [3] [4]
Wikidata
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Interactions

ATF7IP has been shown to interact with MBD1.^[8] In mice with T cell-specific deletion of Atf7ip, the protein has been shown to play a role in regulating T helper 17 cell (Th17) differentiation due to increased IL-2 production upon stimulation of the T cell receptor (TCR). This TCR stimulation occurs through deposition of H3K9me3, a repressive histone mark.^[9][10]