ATOH8 (gene)

Atonal bHLH transcription factor 8 is a protein that in humans is encoded by the ATOH8 gene.^[5] It is hypothesized to play a role endochondral ossification as a regulator of chondrocyte proliferation and differentiation.^[6] In addition, it also participates in the chondrogenesis of limb bud mesenchymal progenitor cells.^[7]

ATOH8
Identifiers
Aliases	ATOH8, HATH6, bHLHa21, atonal bHLH transcription factor 8
External IDs	MGI: 1918343; HomoloGene: 41893; GeneCards: ATOH8; OMA:ATOH8 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p11.2 Start 85,751,344 bp[1] End 85,791,383 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C1 Start 72,183,161 bp[2] End 72,212,561 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland right lung tibial nerve popliteal artery tibial arteries thoracic aorta right auricle of heart ascending aorta apex of heart Top expressed in spermatid gastrula seminiferous tubule spermatocyte tail of embryo genital tubercle endothelial cell of lymphatic vessel aortic valve muscle of thigh ascending aorta More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein dimerization activity DNA-binding transcription factor activity transcription factor binding E-box binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nuclear speck nucleus nucleoplasm Biological process cell differentiation positive regulation of endothelial cell differentiation regulation of transcription, DNA-templated SMAD protein signal transduction transcription, DNA-templated nervous system development negative regulation of endothelial cell proliferation positive regulation of endothelial cell migration positive regulation of transcription, DNA-templated multicellular organism development tube formation myoblast proliferation formation of primary germ layer negative regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II positive regulation of gene expression negative regulation of gene expression positive regulation of pri-miRNA transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84913 71093 Ensembl ENSG00000168874 ENSMUSG00000037621 UniProt Q96SQ7 Q99NA2 RefSeq (mRNA) NM_032827 NM_153778 RefSeq (protein) NP_116216 NP_722473 Location (UCSC) Chr 2: 85.75 – 85.79 Mb Chr 6: 72.18 – 72.21 Mb PubMed search [3] [4]
Wikidata
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