Phospholipid-transporting ATPase VA

Phospholipid-transporting ATPase VA also known as ATPase class V type 10A or aminophospholipid translocase VA is an enzyme that in humans is encoded by the ATP10A gene.^[5][6][7]

ATP10A
Identifiers
Aliases	ATP10A, ATP10C, ATPVA, ATPVC, ATPase phospholipid transporting 10A (putative)
External IDs	OMIM: 605855; MGI: 1330809; HomoloGene: 56461; GeneCards: ATP10A; OMA:ATP10A - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q12 Start 25,677,273 bp[1] End 25,865,184 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B5 Start 58,305,914 bp[2] End 58,479,168 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Descending thoracic aorta ascending aorta tibial arteries dorsal motor nucleus of vagus nerve inferior olivary nucleus glomerulus metanephric glomerulus left coronary artery right coronary artery Top expressed in cumulus cell spermatid gastrula adrenal gland thymus internal carotid artery seminiferous tubule decidua endothelial cell of lymphatic vessel substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding hydrolase activity ATP binding magnesium ion binding metal ion binding ATPase-coupled intramembrane lipid transporter activity Cellular component integral component of membrane plasma membrane endoplasmic reticulum endoplasmic reticulum membrane membrane Biological process phospholipid transport ion transmembrane transport lipid transport phospholipid translocation regulation of cell shape Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57194 11982 Ensembl ENSG00000206190 ENSMUSG00000025324 UniProt O60312 O54827 RefSeq (mRNA) NM_024490 NM_009728 RefSeq (protein) NP_077816 NP_033858 Location (UCSC) Chr 15: 25.68 – 25.87 Mb Chr 7: 58.31 – 58.48 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by ATP10A belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome, also known as 'happy puppet syndrome'.^[8]

See also

• Haloacid dehydrogenase superfamily