Haloacid dehydrogenase superfamily

The haloacid dehydrogenase superfamily (HAD superfamily) is a superfamily of enzymes that include phosphatases, phosphonatases, P-type ATPases, beta-phosphoglucomutases, phosphomannomutases, and dehalogenases, and are involved in a variety of cellular processes ranging from amino acid biosynthesis to detoxification.^[1]

Hydrolase_3
crystal structure of had-like phosphatase yida from e. coli
Identifiers
Symbol	Hydrolase_3
Pfam	PF08282
Pfam clan	CL0137
ECOD	2006.1.1
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Examples

A HAD domain is found in several distinct proteins including:

• Phospholipid-translocating ATPase EC 3.6.3.1, a putative lipid-flipping enzyme involved in cold tolerance in Arabidopsis ^[2]
• 3-deoxy-D-manno-octulosonate (KDO) 8-phosphate phosphatase (EC 3.1.3.45), which catalyses the final step in the biosynthesis of KDO - a component of lipopolysaccharide in Gram-negative bacteria^[3]
• Mannosyl-3-phosphoglycerate phosphatase (EC 3.1.3.70), which hydrolyses mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate^[4]
• Phosphoglycolate phosphatase (EC 3.1.3.18), which catalyses the dephosphorylation of 2-phosphoglycolate^[5]
• 5´-Nucleotidase (EC 3.1.3.5) which either catalyzes the hydrolysis of IMP. or IMP and GMP
• Hypothetical proteins

Human genes encoding proteins that contain this domain include:

• ATP8B3, ATP8B4, ATP10A, ATP10B, ATP10D