ATP12A

Potassium-transporting ATPase alpha chain 2 is a protein that in humans is encoded by the ATP12A gene.^[5][6][7][8]

ATP12A
Identifiers
Aliases	ATP12A, ATP1AL1, #945, HK, ATPase H+/K+ transporting non-gastric alpha2 subunit, H-K-ATPase
External IDs	OMIM: 182360; MGI: 1926943; HomoloGene: 68197; GeneCards: ATP12A; OMA:ATP12A - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q12.12|13q12.1-q12.3 Start 24,680,408 bp[1] End 24,712,472 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C3 Start 56,602,525 bp[2] End 56,626,007 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trachea nasal epithelium olfactory zone of nasal mucosa epithelium of bronchus epithelium of nasopharynx bronchial epithelial cell testicle vulva mucosa of paranasal sinus oral cavity Top expressed in left colon seminal vesicula lip cervix skin of external ear skin of abdomen embryo skin of back left lung lobe blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding metal ion binding ATPase-coupled cation transmembrane transporter activity hydrolase activity ATP binding P-type sodium:potassium-exchanging transporter activity P-type potassium:proton transporter activity P-type potassium transmembrane transporter activity Cellular component integral component of membrane membrane plasma membrane basolateral plasma membrane potassium:proton exchanging ATPase complex Biological process sodium ion transport ion transport potassium ion transport potassium ion homeostasis regulation of pH establishment or maintenance of transmembrane electrochemical gradient proton transmembrane transport cellular sodium ion homeostasis cellular potassium ion homeostasis sodium ion export across plasma membrane potassium ion import across plasma membrane ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 479 192113 Ensembl ENSG00000075673 ENSMUSG00000022229 UniProt P54707 Q9Z1W8 RefSeq (mRNA) NM_001676 NM_001185085 NM_138652 RefSeq (protein) NP_001172014 NP_001667 NP_619593 Location (UCSC) Chr 13: 24.68 – 24.71 Mb Chr 14: 56.6 – 56.63 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H⁺/K⁺ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H⁺ and K⁺ ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.^[6]