ATP1A4

Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.^[5][6][7]

ATP1A4
Identifiers
Aliases	ATP1A4, ATP1A1, ATP1AL2, ATPase Na+/K+ transporting subunit alpha 4
External IDs	OMIM: 607321; MGI: 1351335; HomoloGene: 113769; GeneCards: ATP1A4; OMA:ATP1A4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.2 Start 160,151,586 bp[1] End 160,186,980 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.54 cM Start 172,051,080 bp[2] End 172,085,981 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis testicle sperm seminal vesicula gastrocnemius muscle urinary bladder muscle of thigh gonad lymph node Top expressed in seminiferous tubule spermatid spermatocyte embryo zygote muscle of thigh skeletal muscle tissue subcutaneous adipose tissue white adipose tissue temporal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding P-type sodium:potassium-exchanging transporter activity metal ion binding hydrolase activity ATP binding P-type potassium transmembrane transporter activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane sodium:potassium-exchanging ATPase complex Biological process flagellated sperm motility establishment or maintenance of transmembrane electrochemical gradient sodium ion transport regulation of membrane potential ion transport potassium ion transport regulation of cellular pH spermatogenesis fertilization cellular sodium ion homeostasis cellular potassium ion homeostasis sodium ion export across plasma membrane potassium ion import across plasma membrane ion transmembrane transport regulation of cardiac conduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 480 27222 Ensembl ENSG00000132681 ENSMUSG00000007107 UniProt Q13733 Q9WV27 RefSeq (mRNA) NM_001001734 NM_144699 NM_013734 RefSeq (protein) NP_001001734 NP_653300 NP_038762 Location (UCSC) Chr 1: 160.15 – 160.19 Mb Chr 1: 172.05 – 172.09 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.^[7]