ATP2A3

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 is an enzyme that in humans is encoded by the ATP2A3 gene.^[5][6]

ATP2A3
Identifiers
Aliases	ATP2A3, SERCA3, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
External IDs	OMIM: 601929; MGI: 1194503; HomoloGene: 69131; GeneCards: ATP2A3; OMA:ATP2A3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 3,923,870 bp[1] End 3,964,464 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B4 Start 72,851,995 bp[2] End 72,883,870 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte olfactory zone of nasal mucosa spleen mucosa of transverse colon thymus lymph node blood bone marrow cells beta cell appendix Top expressed in submandibular gland parotid gland granulocyte islet of Langerhans pyloric antrum crypt of lieberkuhn of small intestine colon left colon thymus tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding P-type calcium transporter activity metal ion binding hydrolase activity ATP binding P-type proton-exporting transporter activity Cellular component integral component of membrane nuclear membrane endoplasmic reticulum membrane membrane sarcoplasmic reticulum platelet dense tubular network membrane endoplasmic reticulum nucleus sarcoplasmic reticulum membrane Biological process regulation of cardiac conduction ion transport ion transmembrane transport calcium ion transmembrane transport calcium ion transport cellular calcium ion homeostasis proton transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 489 53313 Ensembl ENSG00000074370 ENSMUSG00000020788 UniProt Q93084 Q64518 RefSeq (mRNA) NM_005173 NM_174953 NM_174954 NM_174955 NM_174956 NM_174957 NM_174958 NM_001163336 NM_001163337 NM_016745 RefSeq (protein) NP_005164 NP_777613 NP_777614 NP_777615 NP_777616 NP_777617 NP_777618 NP_001156808 NP_001156809 NP_058025 Location (UCSC) Chr 17: 3.92 – 3.96 Mb Chr 11: 72.85 – 72.88 Mb PubMed search [3] [4]
Wikidata
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This gene encodes one of the SERCA Ca²⁺-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of cells. SERCA3 expression was originally described as non-muscular, but was recently observed in cardiomyocyte. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in 6 transcript variants encoding different isoforms named SERCA3a to SERCA3f.^[6]

Cancer

ATP2A3 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.^[7] For this reason, ATP2A3 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.^[7]