ATP2B4

Plasma membrane calcium-transporting ATPase 4 is an enzyme that in humans is encoded by the ATP2B4 gene.^[5][6]

ATP2B4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CFF, 2KNE
Identifiers
Aliases	ATP2B4, ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x, ATPase plasma membrane Ca2+ transporting 4
External IDs	OMIM: 108732; MGI: 88111; HomoloGene: 48034; GeneCards: ATP2B4; OMA:ATP2B4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 203,626,787 bp[1] End 203,744,081 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 E4|1 57.95 cM Start 133,627,195 bp[2] End 133,728,779 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein tail of epididymis body of uterus myometrium epithelium of colon smooth muscle tissue left uterine tube muscle layer of sigmoid colon superficial temporal artery skin of arm Top expressed in spermatocyte superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell lip spermatid Rostral migratory stream esophagus genital tubercle ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding PDZ domain binding sodium channel regulator activity nitric-oxide synthase binding scaffold protein binding metal ion binding calmodulin binding nitric-oxide synthase inhibitor activity protein binding protein phosphatase 2B binding ATP binding hydrolase activity P-type calcium transporter activity protein kinase binding Cellular component integral component of membrane cell projection membrane intracellular membrane-bounded organelle T-tubule plasma membrane integral component of plasma membrane sperm flagellum sperm principal piece basolateral plasma membrane Z discdkac caveola neuron projection sarcolemma cilium motile cilium protein-containing complex glutamatergic synapse integral component of presynaptic active zone membrane Biological process negative regulation of nitric oxide mediated signal transduction flagellated sperm motility regulation of cardiac conduction negative regulation of nitric-oxide synthase activity negative regulation of calcineurin-NFAT signaling cascade negative regulation of citrulline biosynthetic process negative regulation of peptidyl-cysteine S-nitrosylation regulation of transcription by RNA polymerase II calcium ion import across plasma membrane response to hydrostatic pressure cellular calcium ion homeostasis ion transport positive regulation of peptidyl-serine phosphorylation cellular response to epinephrine stimulus ion transmembrane transport negative regulation of nitric oxide biosynthetic process calcium ion transmembrane transport calcium ion transmembrane import into cytosol spermatogenesis positive regulation of cAMP-dependent protein kinase activity regulation of cell cycle G1/S phase transition regulation of sodium ion transmembrane transport calcium ion export hippocampus development negative regulation of arginine catabolic process neural retina development negative regulation of the force of heart contraction calcium ion transport negative regulation of cardiac muscle hypertrophy in response to stress transport regulation of cytosolic calcium ion concentration negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process urinary bladder smooth muscle contraction cellular response to acetylcholine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 493 381290 Ensembl ENSG00000058668 ENSMUSG00000026463 UniProt P23634 Q6Q477 RefSeq (mRNA) NM_001684 NM_001001396 NM_001365783 NM_001365784 NM_001167949 NM_213616 RefSeq (protein) NP_001001396 NP_001675 NP_001352712 NP_001352713 NP_001161421 NP_998781 Location (UCSC) Chr 1: 203.63 – 203.74 Mb Chr 1: 133.63 – 133.73 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]

Interactions

ATP2B4 has been shown to interact with CASK.^[7]