ATP5B

ATP synthase F1 subunit beta, mitochondrial is an enzyme that in humans is encoded by the ATP5F1B gene.^[5][6]

ATP5F1B
Identifiers
Aliases	ATP5F1B, ATPMB, ATPSB, HEL-S-271, ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide, ATP synthase F1 subunit beta, ATP5B
External IDs	OMIM: 102910; MGI: 107801; HomoloGene: 1273; GeneCards: ATP5F1B; OMA:ATP5F1B - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 56,638,175 bp[1] End 56,645,984 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 127,919,142 bp[2] End 127,926,260 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart left ventricle right auricle of heart right ventricle myocardium of left ventricle mucosa of transverse colon cerebellar cortex right hemisphere of cerebellum muscle of thigh gastrocnemius muscle Top expressed in right kidney dentate gyrus of hippocampal formation granule cell myocardium of ventricle right ventricle atrium central gray substance of midbrain mandibular prominence cardiac muscles human kidney maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding transmembrane transporter activity transporter activity proton-transporting ATPase activity, rotational mechanism ATPase activity protein binding MHC class I protein binding hydrolase activity ATP binding angiostatin binding proton-transporting ATP synthase activity, rotational mechanism Cellular component mitochondrial proton-transporting ATP synthase complex membrane mitochondrial membranes myelin sheath plasma membrane cell surface mitochondrial matrix mitochondrial proton-transporting ATP synthase, catalytic core mitochondrion mitochondrial inner membrane proton-transporting ATP synthase complex, catalytic core F(1) mitochondrial nucleoid extracellular exosome nucleus extracellular matrix proton-transporting ATP synthase complex proton-transporting two-sector ATPase complex, catalytic domain Biological process lipid metabolism mitochondrial ATP synthesis coupled proton transport mitochondrion organization regulation of intracellular pH ion transport generation of precursor metabolites and energy negative regulation of cell adhesion involved in substrate-bound cell migration ATP metabolic process angiogenesis osteoblast differentiation ATP synthesis coupled proton transport ATP biosynthetic process cristae formation positive regulation of blood vessel endothelial cell migration transport cellular response to interleukin-7 proton transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 506 11947 Ensembl ENSG00000110955 ENSMUSG00000025393 UniProt P06576 P56480 RefSeq (mRNA) NM_001686 NM_016774 RefSeq (protein) NP_001677 NP_058054 Location (UCSC) Chr 12: 56.64 – 56.65 Mb Chr 10: 127.92 – 127.93 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core.^[6]