ATP5G2

The ATP5MC2 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.^[5][6]

ATP5MC2
Identifiers
Aliases	ATP5MC2, ATP5A, ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9), ATP synthase membrane subunit c locus 2, ATP5G2
External IDs	OMIM: 603193; MGI: 1915192; HomoloGene: 57052; GeneCards: ATP5MC2; OMA:ATP5MC2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 53,632,726 bp[1] End 53,677,408 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 F3 Start 102,571,299 bp[2] End 102,580,787 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle of thigh gastrocnemius muscle islet of Langerhans right uterine tube muscle layer of sigmoid colon anterior pituitary body of stomach embryo granulocyte Top expressed in embryo blastocyst embryo quadriceps femoris muscle neural tube right kidney stomach epiblast esophagus yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function proton transmembrane transporter activity lipid binding transporter activity proton-transporting ATP synthase activity, rotational mechanism protein binding Cellular component proton-transporting ATP synthase complex, coupling factor F(o) integral component of membrane mitochondrial outer membrane proton-transporting two-sector ATPase complex, proton-transporting domain mitochondrial proton-transporting ATP synthase complex membrane mitochondrion mitochondrial membranes mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Biological process ion transport ATP biosynthetic process ATP synthesis coupled proton transport cristae formation mitochondrial ATP synthesis coupled proton transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 517 67942 Ensembl ENSG00000135390 ENSMUSG00000062683 UniProt Q06055 P56383 RefSeq (mRNA) NM_001002031 NM_005176 NM_001330269 NM_026468 RefSeq (protein) NP_001002031 NP_001317198 NP_005167 NP_001356682 NP_001356683 NP_001356684 NP_001356685 NP_001356686 NP_001356687 NP_080744 Location (UCSC) Chr 12: 53.63 – 53.68 Mb Chr 15: 102.57 – 102.58 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). There are three separate genes which encode subunit c of the proton channel and they specify precursors with different import sequences but identical mature proteins. The protein encoded by this gene is one of three precursors of subunit c. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene has multiple pseudogenes.^[6]