ATP8B3

The human gene ATP8B3 encodes the protein ATPase, aminophospholipid transporter, class I, type 8B, member 3.^[5]

ATP8B3
Identifiers
Aliases	ATP8B3, ATPIK, ATPase phospholipid transporting 8B3
External IDs	OMIM: 605866; MGI: 1914581; HomoloGene: 19034; GeneCards: ATP8B3; OMA:ATP8B3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 1,782,075 bp[1] End 1,812,276 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 80,355,418 bp[2] End 80,374,958 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis buccal mucosa cell stromal cell of endometrium right adrenal gland right adrenal cortex granulocyte testicle left adrenal gland left adrenal cortex Top expressed in spermatid spermatocyte seminiferous tubule olfactory epithelium embryo facial motor nucleus epiblast islet of Langerhans tail of embryo anterior horn of spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding metal ion binding ATPase-coupled intramembrane lipid transporter activity hydrolase activity ATP binding magnesium ion binding Cellular component integral component of membrane Golgi apparatus endoplasmic reticulum membrane membrane plasma membrane acrosomal membrane endoplasmic reticulum cytoplasmic vesicle acrosomal vesicle Biological process lipid transport Golgi organization phospholipid transport phospholipid translocation binding of sperm to zona pellucida Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 148229 67331 Ensembl ENSG00000130270 ENSMUSG00000003341 UniProt O60423 Q6UQ17 RefSeq (mRNA) NM_001178002 NM_138813 NM_026094 RefSeq (protein) NP_001171473 NP_620168 NP_080370 Location (UCSC) Chr 19: 1.78 – 1.81 Mb Chr 10: 80.36 – 80.37 Mb PubMed search [3] [4]
Wikidata
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Transcript

Alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[5]

Protein

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene encodes the member 3 of the phospholipid-transporting ATPase 8B.