ATPIF1

ATPase inhibitor, mitochondrial is an enzyme that in humans is encoded by the ATPIF1 gene.^[5][6]

ATP5IF1
Identifiers
Aliases	ATP5IF1, ATPI, ATPIP, IP, ATPase inhibitory factor 1, ATP synthase inhibitory factor subunit 1, ATPIF1
External IDs	OMIM: 614981; MGI: 1196457; HomoloGene: 40581; GeneCards: ATP5IF1; OMA:ATP5IF1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.3 Start 28,236,109 bp[1] End 28,246,906 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.3 Start 132,257,866 bp[2] End 132,260,970 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis apex of heart right testis Brodmann area 9 prefrontal cortex mucosa of transverse colon superior frontal gyrus primary visual cortex olfactory zone of nasal mucosa right auricle of heart Top expressed in Paneth cell epithelium of small intestine atrium Ileal epithelium external carotid artery migratory enteric neural crest cell proximal tubule right kidney internal carotid artery medial vestibular nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 5-formyltetrahydrofolate cyclo-ligase activity enzyme inhibitor activity protein homodimerization activity ATPase binding calmodulin binding ATPase inhibitor activity angiostatin binding enzyme binding mitochondrial proton-transporting ATP synthase complex binding Cellular component mitochondrial proton-transporting ATP synthase complex cell surface mitochondrion Biological process regulation of ATP metabolic process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway negative regulation of ATP-dependent activity tetrahydrofolate interconversion positive regulation of proteolysis involved in cellular protein catabolic process negative regulation of hydrolase activity generation of precursor metabolites and energy reactive oxygen species metabolic process negative regulation of endothelial cell proliferation heme biosynthetic process regulation of protein targeting to mitochondrion angiogenesis erythrocyte differentiation mitochondrial depolarization protein homooligomerization protein homotetramerization folic acid-containing compound biosynthetic process positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 93974 11983 Ensembl ENSG00000130770 ENSG00000285390 ENSMUSG00000054428 UniProt Q9UII2 O35143 RefSeq (mRNA) NM_178191 NM_016311 NM_178190 NM_007512 RefSeq (protein) NP_057395 NP_835497 NP_835498 NP_031538 Location (UCSC) Chr 1: 28.24 – 28.25 Mb Chr 4: 132.26 – 132.26 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified.^[6]

It prevents ATPase from switching to ATP hydrolysis during collapse of the electrochemical gradient, for example during oxygen deprivation ^[7] ATP synthase inhibitor forms a one-to-one complex with the F1 ATPase, possibly by binding at the alpha-beta interface. It is thought to inhibit ATP synthesis by preventing the release of ATP.^[8] The inhibitor has two oligomeric states, dimer (the active state) and tetramer. At low pH, the inhibitor forms a dimer via antiparallel coiled coil interactions between the C-terminal regions of two monomers. At high pH, the inhibitor forms tetramers and higher oligomers by coiled coil interactions involving the N terminus and inhibitory region, thus preventing the inhibitory activity.^[7]

Mitochondrial ATPase inhibitor, IATP
c-terminal coiled-coil domain from bovine if1
Identifiers
Symbol	IATP
Pfam	PF04568
InterPro	IPR007648
SCOP2	1hf9 / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary