AZIN1

Antizyme inhibitor 1 is a protein that in humans is encoded by the AZIN1 gene.^[5][6][7]

AZIN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZGZ
Identifiers
Aliases	AZIN1, AZI, AZIA1, OAZI, OAZIN, ODC1L, antizyme inhibitor 1, AZI1
External IDs	OMIM: 607909; MGI: 1859169; HomoloGene: 22933; GeneCards: AZIN1; OMA:AZIN1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.3 Start 102,826,111 bp[1] End 102,893,864 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B3.1 Start 38,487,671 bp[2] End 38,519,510 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell ventricular zone epithelium of nasopharynx ganglionic eminence epithelium of colon cartilage tissue placenta bone marrow cell jejunal mucosa body of pancreas Top expressed in fetal liver hematopoietic progenitor cell atrioventricular valve barrel cortex spermatocyte decidua lacrimal gland atrium epithelium of lens spermatid salivary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ornithine decarboxylase activator activity protein binding catalytic activity ornithine decarboxylase activity Cellular component cytosol nucleus cytoplasm Biological process polyamine biosynthetic process positive regulation of polyamine transmembrane transport regulation of cellular amino acid metabolic process putrescine biosynthetic process from ornithine positive regulation of catalytic activity negative regulation of protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51582 54375 Ensembl ENSG00000155096 ENSMUSG00000037458 UniProt O14977 O35484 RefSeq (mRNA) NM_001301668 NM_015878 NM_148174 NM_001363010 NM_001363011 NM_001363012 NM_001363013 NM_001363014 NM_001363024 NM_001363083 NM_001102458 NM_001301688 NM_018745 RefSeq (protein) NP_001288597 NP_056962 NP_680479 NP_001349939 NP_001349940 NP_001349941 NP_001349942 NP_001349943 NP_001349953 NP_001350012 NP_001095928 NP_001288617 NP_061215 Location (UCSC) Chr 8: 102.83 – 102.89 Mb Chr 15: 38.49 – 38.52 Mb PubMed search [3] [4]
Wikidata
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Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene.^[7]