Ac-SDKP

Ac-SDKP (Thymosin Beta 4 Fragment (1–4), Goralatide) is an endogenous tetrapeptide derivative that is the N-acetylated derivative of the fragment composed of amino acids 1-4 derived from cleavage of the N-terminus of the signalling factor thymosin beta-4 by the enzyme prolyl oligopeptidase. It is a selective inhibitor of haematopoietic cell proliferation and has antiinflammatory, anti-fibrotic, and pro-angiogenic properties, with particular applications in preventing the development of kidney fibrosis and cardiac fibrosis following injury to these organs.^{[1][2][3][4][5][6][7][8][9]}

Ac-SDKP

Identifiers
IUPAC name (2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carboxylic acid
CAS Number	120081-14-3
PubChem CID	65938
IUPHAR/BPS	10060
ChemSpider	59343
UNII	H041538E9P
ChEBI	CHEBI:191178
ChEMBL	ChEMBL420741
Chemical and physical data
Formula	C38H68N10O14
Molar mass	889.018 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)O
InChI InChI=1S/C20H33N5O9/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34)/t12-,13-,14-,15-/m0/s1 Key:HJDRXEQUFWLOGJ-AJNGGQMLSA-N

See also

• Adamax
• BPC-157
• CJC-1295
• KPV tripeptide
• TB-500