Ae binding protein 1

AE binding protein 1 is a protein that in humans is encoded by the AEBP1 gene.^[5]

AEBP1
Identifiers
Aliases	AEBP1, ACLP, AE binding protein 1
External IDs	OMIM: 602981; MGI: 1197012; HomoloGene: 878; GeneCards: AEBP1; OMA:AEBP1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 44,104,345 bp[1] End 44,114,562 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 5,811,947 bp[2] End 5,822,088 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii thoracic aorta ascending aorta right coronary artery Descending thoracic aorta popliteal artery tibial arteries left coronary artery saphenous vein canal of the cervix Top expressed in ascending aorta aortic valve calvaria tunica media of zone of aorta uterus cervix body of femur adrenal gland stroma of bone marrow tunica adventitia of aorta More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription corepressor activity DNA-binding transcription factor activity zinc ion binding calmodulin binding DNA-binding transcription repressor activity, RNA polymerase II-specific metallocarboxypeptidase activity carboxypeptidase activity serine-type carboxypeptidase activity extracellular matrix structural constituent collagen binding Cellular component cytoplasm extracellular matrix extracellular exosome nucleus extracellular space extracellular region collagen-containing extracellular matrix Biological process skeletal system development regulation of transcription, DNA-templated peptide metabolic process protein processing muscle organ development negative regulation of transcription by RNA polymerase II transcription, DNA-templated proteolysis regulation of collagen fibril organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 165 11568 Ensembl ENSG00000106624 ENSMUSG00000020473 UniProt Q8IUX7 Q640N1 RefSeq (mRNA) NM_001129 NM_001291857 NM_009636 RefSeq (protein) NP_001120 NP_001278786 NP_033766 Location (UCSC) Chr 7: 44.1 – 44.11 Mb Chr 11: 5.81 – 5.82 Mb PubMed search [3] [4]
Wikidata
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Function

AE binding protein 1 is a member of carboxypeptidase A protein family. The protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that the AEBP1 gene that encodes the protein functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma.^[5]