Alpha-1D adrenergic receptor

The alpha-1D adrenergic receptor (α_1D adrenoreceptor), also known as ADRA1D, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.^[5]

ADRA1D
Identifiers
Aliases	ADRA1D, ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2, adrenoceptor alpha 1D
External IDs	OMIM: 104219; MGI: 106673; HomoloGene: 551; GeneCards: ADRA1D; OMA:ADRA1D - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 4,220,630 bp[1] End 4,249,287 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 63.5 cM Start 131,387,770 bp[2] End 131,404,203 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle Descending thoracic aorta ascending aorta canal of the cervix ectocervix stromal cell of endometrium prefrontal cortex lateral nuclear group of thalamus tibial nerve gastric mucosa Top expressed in hippocampus proper primary visual cortex dentate gyrus of hippocampal formation granule cell olfactory bulb superior frontal gyrus white adipose tissue adrenal gland embryo cerebellar cortex embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity adrenergic receptor activity protein binding alpha1-adrenergic receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane intracellular anatomical structure Biological process G protein-coupled receptor signaling pathway norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure adenylate cyclase-modulating G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling DNA metabolic process multicellular organism development adenylate cyclase-activating adrenergic receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway positive regulation of vasoconstriction positive regulation of cell population proliferation cell population proliferation positive regulation of smooth muscle contraction signal transduction neuron-glial cell signaling adrenergic receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 146 11550 Ensembl ENSG00000171873 ENSMUSG00000027335 UniProt P25100 P97714 RefSeq (mRNA) NM_000678 NM_013460 RefSeq (protein) NP_000669 NP_000669.1 NP_038488 Location (UCSC) Chr 20: 4.22 – 4.25 Mb Chr 2: 131.39 – 131.4 Mb PubMed search [3] [4]
Wikidata
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Receptor

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.^[5]

Ligands

Many α₁ receptor ligands are non-selective for receptor subtypes.

Antagonists

• A-315456^[6]
• BMY 7378 (also α_2C antagonist)^[7]
• Domesticine^[8]
• Cyclazosin (slight α_1C selectivity)^[9]
• Tamsulosin (roughly equal affinity for α_1A)^[9]

See also

• Adrenergic receptor