Alpha-2A adrenergic receptor

The alpha-2A adrenergic receptor (α_2A adrenoceptor), also known as ADRA2A, is an α₂-adrenergic receptor, and also denotes the human gene encoding it.^[5]

ADRA2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HLL, 1HO9, 1HOD, 1HOF
Identifiers
Aliases	ADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32, adrenoceptor alpha 2A
External IDs	OMIM: 104210; MGI: 87934; HomoloGene: 47944; GeneCards: ADRA2A; OMA:ADRA2A - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.2 Start 111,077,029 bp[1] End 111,080,907 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 D2|19 49.04 cM Start 54,032,582 bp[2] End 54,037,413 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in subcutaneous adipose tissue canal of the cervix ectocervix mucosa of transverse colon pericardium gallbladder ganglionic eminence body of pancreas abdominal fat lactiferous gland Top expressed in pontine nuclei lateral septal nucleus islet of Langerhans stroma of bone marrow dorsomedial hypothalamic nucleus lumbar subsegment of spinal cord subiculum gastrula mammillary body medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function alpha-2C adrenergic receptor binding G protein-coupled receptor activity protein homodimerization activity epinephrine binding norepinephrine binding alpha-1B adrenergic receptor binding signal transducer activity adrenergic receptor activity protein binding alpha2-adrenergic receptor activity protein heterodimerization activity thioesterase binding heterotrimeric G-protein binding protein kinase binding Cellular component integral component of membrane membrane receptor complex plasma membrane integral component of plasma membrane basolateral plasma membrane cytoplasm Biological process G protein-coupled receptor signaling pathway positive regulation of epidermal growth factor-activated receptor activity activation of protein kinase B activity negative regulation of insulin secretion positive regulation of MAP kinase activity negative regulation of epinephrine secretion glucose homeostasis regulation of smooth muscle contraction positive regulation of cytokine production regulation of insulin secretion positive regulation of cell migration positive regulation of potassium ion transport phospholipase C-activating adrenergic receptor signaling pathway positive regulation of wound healing negative regulation of norepinephrine secretion positive regulation of membrane protein ectodomain proteolysis negative regulation of insulin secretion involved in cellular response to glucose stimulus adenylate cyclase-inhibiting adrenergic receptor signaling pathway negative regulation of calcium ion transmembrane transporter activity cellular response to hormone stimulus regulation of vasoconstriction negative regulation of calcium ion-dependent exocytosis Rho protein signal transduction positive regulation of cell population proliferation negative regulation of calcium ion transport intestinal absorption Ras protein signal transduction negative regulation of lipid catabolic process activation of protein kinase activity actin cytoskeleton organization signal transduction platelet activation positive regulation of MAPK cascade adrenergic receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway receptor transactivation adenylate cyclase-modulating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 150 11551 Ensembl ENSG00000150594 ENSMUSG00000033717 UniProt P08913 Q01338 RefSeq (mRNA) NM_000681 NM_007417 RefSeq (protein) NP_000672 NP_031443 Location (UCSC) Chr 10: 111.08 – 111.08 Mb Chr 19: 54.03 – 54.04 Mb PubMed search [3] [4]
Wikidata
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Receptor

α₂-adrenergic receptors include 3 highly homologous subtypes: α_2A, α_2B, and α_2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mice revealed that both the α_2A and α_2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the α_2A subtype inhibited transmitter release at high stimulation frequencies, whereas the α_2C subtype modulated neurotransmission at lower levels of nerve activity.^[6]

Gene

This gene encodes α_2A subtype and it contains no introns in either its coding or untranslated sequences.^[5]

Ligands

Agonists

• 4-NEMD
• Brimonidine
• Clonidine
• Detomidine
• Dexmedetomidine
• Guanfacine
• Lofexidine
• Myrcene
• Medetomidine
• PS75^[7]
• Tizanidine
• Xylazine

Antagonists

• Atipamezole
• Idazoxan
• 1-PP (active metabolite of buspirone and gepirone)
• Asenapine
• BRL-44408
• Clozapine
• Lurasidone
• Mianserin
• Mirtazapine
• Paliperidone
• Risperidone
• Yohimbine

See also

• Adrenergic receptor