ANGPT2

Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene.^[5]

ANGPT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z3S, 1Z3U, 2GY7, 4JZC, 4ZFG
Identifiers
Aliases	ANGPT2, AGPT2, ANG2, angiopoietin 2, LMPHM10
External IDs	OMIM: 601922; MGI: 1202890; HomoloGene: 22401; GeneCards: ANGPT2; OMA:ANGPT2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p23.1 Start 6,499,632 bp[1] End 6,563,409 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.3|8 10.3 cM Start 18,740,279 bp[2] End 18,791,578 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii popliteal artery tibial arteries placenta islet of Langerhans visceral pleura subcutaneous adipose tissue pericardium internal globus pallidus buccal mucosa cell Top expressed in gastrula endothelial cell of lymphatic vessel decidua lumbar spinal ganglion external carotid artery internal carotid artery ascending aorta umbilical cord stroma of kidney stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding signaling receptor binding protein binding receptor tyrosine kinase binding Cellular component cell projection nucleus plasma membrane extracellular region extracellular space Biological process angiogenesis response to hypoxia response to mechanical stimulus negative regulation of positive chemotaxis response to radiation negative regulation of cell-substrate adhesion signal transduction animal organ regeneration response to activity Tie signaling pathway cellular response to growth factor stimulus multicellular organism development maternal process involved in female pregnancy negative regulation of angiogenesis response to organic cyclic compound leukocyte migration negative regulation of blood vessel endothelial cell migration blood vessel morphogenesis germ cell development positive regulation of angiogenesis response to glucose cell differentiation glomerulus vasculature development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 285 11601 Ensembl ENSG00000091879 ENSMUSG00000031465 UniProt O15123 O35608 RefSeq (mRNA) NM_001147 NM_001118887 NM_001118888 NM_001386335 NM_001386336 NM_001386337 NM_007426 RefSeq (protein) NP_001112359 NP_001112360 NP_001138 NP_031452 Location (UCSC) Chr 8: 6.5 – 6.56 Mb Chr 8: 18.74 – 18.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1^[6]

Function

• See Angiopoietin#Clinical relevance

Interactions

ANGPT2 has been shown to interact with TEK tyrosine kinase.^[7][8][9]

See also

• Angiopoietin