Apelin receptor

The Apelin Receptor (APLNR, also known as APJ) is a G protein-coupled receptor.^[5] APLNR possesses two endogenous ligands which are APELIN^[6][7][8] and ELABELA.^[9][10] The structure of APLNR was resolved in 2017^[11]

APLNR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LOT, 2LOU, 2LOV, 2LOW
Identifiers
Aliases	APLNR, AGTRL1, APJ, APJR, HG11, apelin receptor
External IDs	OMIM: 600052; MGI: 1346086; HomoloGene: 3784; GeneCards: APLNR; OMA:APLNR - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.1 Start 57,233,577 bp[1] End 57,237,250 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 D Start 84,966,569 bp[2] End 84,970,267 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in optic nerve inferior olivary nucleus dorsal motor nucleus of vagus nerve tendon of biceps brachii ventral tegmental area spinal cord C1 segment Region I of hippocampus proper myocardium of left ventricle spleen Top expressed in renal corpuscle left lung lobe dermis medullary collecting duct body of femur vas deferens internal carotid artery primitive streak digastric muscle migratory enteric neural crest cell More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity signaling receptor activity apelin receptor activity Cellular component integral component of membrane integral component of plasma membrane membrane plasma membrane Biological process multicellular organism development heart development regulation of body fluid levels gastrulation signal transduction G protein-coupled receptor signaling pathway negative regulation of cAMP-mediated signaling positive regulation of angiogenesis positive regulation of release of sequestered calcium ion into cytosol positive regulation of inhibitory G protein-coupled receptor phosphorylation vasculogenesis adult heart development coronary vasculature development positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis angiogenesis blood vessel development apelin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 187 23796 Ensembl ENSG00000134817 ENSMUSG00000044338 UniProt P35414 Q9WV08 RefSeq (mRNA) NM_005161 NM_011784 RefSeq (protein) NP_005152 NP_035914 Location (UCSC) Chr 11: 57.23 – 57.24 Mb Chr 2: 84.97 – 84.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse