Apolipoprotein C-IV

Apolipoprotein C-IV, also known as apolipoprotein C4, is a protein that in humans is encoded by the APOC4 gene.^[5][6]

APOC4
Identifiers
Aliases	APOC4, APO-CIV, APOC-IV, apolipoprotein C4
External IDs	OMIM: 600745; MGI: 87878; HomoloGene: 1245; GeneCards: APOC4; OMA:APOC4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 44,942,237 bp[1] End 44,945,496 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 9.94 cM Start 19,412,008 bp[2] End 19,415,404 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver testicle mucosa of transverse colon sural nerve left adrenal cortex right adrenal gland right ovary ventricular zone right adrenal cortex gallbladder Top expressed in left lobe of liver gallbladder adrenal gland fetal liver hematopoietic progenitor cell yolk sac sexually immature organism human fetus embryo morula stomach More reference expression data BioGPS n/a
Gene ontology Molecular function lipid transporter activity Cellular component high-density lipoprotein particle extracellular region very-low-density lipoprotein particle Biological process lipid transport positive regulation of sequestering of triglyceride triglyceride homeostasis lipid metabolism very-low-density lipoprotein particle assembly very-low-density lipoprotein particle clearance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 346 11425 Ensembl ENSG00000267467 ENSMUSG00000074336 UniProt P55056 Q61268 RefSeq (mRNA) NM_001646 NM_007385 RefSeq (protein) NP_001637 NP_031411 Location (UCSC) Chr 19: 44.94 – 44.95 Mb Chr 7: 19.41 – 19.42 Mb PubMed search [3] [4]
Wikidata
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Function

APOC4 is a member of the apolipoprotein C gene family. It is expressed in the liver and has a predicted protein structure characteristic of the other genes in this family. APOC4 is a 3.3-kb gene consisting of 3 exons and 2 introns; it is located 0.5 kb 5' to the APOC2 gene.^[5]