Apolipoprotein O

Apolipoprotein O also known as protein FAM121B is a protein that in humans is encoded by the APOO gene. APOO is a member of the apolipoprotein family.^[5]

APOO
Identifiers
Aliases	APOO, FAM121B, MIC26, Mic23, My025, Apolipoprotein O, MICOS26
External IDs	OMIM: 300753; MGI: 1915566; HomoloGene: 11475; GeneCards: APOO; OMA:APOO - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.11 Start 23,833,353 bp[1] End 23,907,938 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X C3 Start 93,410,723 bp[2] End 93,460,699 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua right ventricle myocardium of left ventricle prefrontal cortex pons olfactory zone of nasal mucosa lateral nuclear group of thalamus triceps brachii muscle Brodmann area 9 anterior cingulate cortex Top expressed in quadriceps femoris muscle right kidney muscle of thigh proximal tubule muscle tissue skeletal muscle tissue heart secondary oocyte primary oocyte zygote More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component high-density lipoprotein particle extracellular region mitochondrial inner membrane endoplasmic reticulum membrane very-low-density lipoprotein particle Golgi membrane Golgi apparatus membrane integral component of membrane integral component of mitochondrial inner membrane mitochondrion endoplasmic reticulum low-density lipoprotein particle MICOS complex extracellular space cytosol Biological process lipid transport cristae formation transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79135 68316 Ensembl ENSG00000184831 ENSMUSG00000079508 UniProt Q9BUR5 Q9DCZ4 RefSeq (mRNA) NM_024122 NM_001199337 NM_001199338 NM_001199339 NM_026673 RefSeq (protein) NP_077027 NP_001186266 NP_001186267 NP_001186268 NP_080949 Location (UCSC) Chr X: 23.83 – 23.91 Mb Chr X: 93.41 – 93.46 Mb PubMed search [3] [4]
Wikidata
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ApoO
Identifiers
Symbol	ApoO
Pfam	PF09769
InterPro	IPR019166
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The human, apolipoprotein O is a 198 amino acids protein that contains a 23 amino acids long signal peptide. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. Apolipoprotein O is the first chondroitine sulphate chain containing apolipoprotein.^[5]

Apolipoproteins are proteins that binds to lipids. Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL.