Arylalkylamine

Substituted arylalkylamines, also alternatively known in many cases as substituted arylethylamines,^[1] are a group of chemical compounds.^[2][3][4][5] These compounds are divided into two main categories: indolylalkylamines and phenylalkylamines.^[2][5]

• Indolylalkylamines include substances like tryptamines, which are found in some natural compounds and can affect mood and perception.^[2]
• Phenylalkylamines include substances like phenethylamines and amphetamines, which are found in both natural and synthetic forms.^[2][5]

These compounds are related to monoamine neurotransmitters, which are chemicals in the brain that transmit signals between nerve cells. Because of this, substituted arylalkylamines can have a wide range of effects on the body and mind. They are used in many medications, including:

• Psychostimulants, which increase alertness and energy.
• Anorectics, which suppress appetite.
• Wakefulness-promoting agents, which help people stay awake.
• Bronchodilators, which make breathing easier.
• Decongestants, which relieve nasal congestion.
• Antidepressants, which are used to treat depression.
• Entactogens, which enhance feelings of emotional closeness.
• Psychedelics, which alter perception and consciousness.

Many arylalkylamines act as monoamine releasing agents, monoamine reuptake inhibitors, and/or monoamine receptor modulators.

Examples of arylalkylamines and related compounds of different classes

• 
  Phenethylamine
• 
  Thiopropamine
• 
  2-Furylethylamine
• 
  2-Tetrahydrofurylethylamine
• 
  2-Pyrrolylethylamine
• 
  3-Pyrrolylethylamine
• 
  Cyclopentamine
• 
  Propylhexedrine
• 
  Tryptamine
• 
  Isotryptamine
• 
  1ZP2MA
• 
  3-APB
• 
  3-APBT
• 
  Methylhexanamine
• 
  Histamine
• 
  Muscimol

Many more foundational arylalkylamines besides the above also exist.^[5] In addition, other alkylamines and non-aromatic cyclized alkylamines exist.^[6]

See also

• Amine
• Alkylamines (disambiguation)
• Arylamine