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3-APB

Pharmaceutical compound From Wikipedia, the free encyclopedia

3-APB
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3-APB, also known as 3-(2-aminopropyl)benzofuran, is a drug of the benzofuran family related to α-methyltryptamine (AMT).[1][2] It is an analogue of AMT in which the indole ring has been replaced with a benzofuran ring.[1][2]

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The properties of 3-APB do not yet appear to have been reported.[1] However, derivatives of 3-APB have been studied and described.[1][3][4][5] An example is its 5-methoxy analogue mebfap (5-MeO-3-APB; a benzofuran analogue of 5-MeO-AMT), which is known to have high affinity for the serotonin 5-HT2 receptors.[1][3][4][5] In addition, 3-APBT, the analogue of 3-APB with a sulfur atom instead of an oxygen atom, is a highly potent serotonin–norepinephrine–dopamine releasing agent (SNDRA) and serotonin receptor agonist, with psychedelic-like but not stimulant-like effects in animals.[6][1]

Positional isomers of 3-APB such as 5-APB and 6-APB are monoamine releasing agents and entactogens of the amphetamine and benzofuran families.[7][8][9] Besides 3-APBT, all of the possible positional isomers of the APBTs (i.e., 2-APBT through 7-APBT) are active as potent SNDRAs and at least some also as serotonin 5-HT2 receptor agonists.[1][6]

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