Asialoglycoprotein receptor 1

Asialoglycoprotein receptor 1 is a protein that in humans is encoded by the ASGR1 gene.^[5]

ASGR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DV8
Identifiers
Aliases	ASGR1, ASGPR, ASGPR1, CLEC4H1, HL-1, asialoglycoprotein receptor 1
External IDs	OMIM: 108360; MGI: 88081; HomoloGene: 1263; GeneCards: ASGR1; OMA:ASGR1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 7,173,431 bp[1] End 7,179,564 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B3|11 42.98 cM Start 69,944,911 bp[2] End 69,948,720 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver monocyte granulocyte left testis cerebellar hemisphere right hemisphere of cerebellum right testis ganglionic eminence right frontal lobe blood Top expressed in left lobe of liver gallbladder embryo lacrimal gland parotid gland embryo optic nerve dentate gyrus of hippocampal formation granule cell trachea cerebellar cortex More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding carbohydrate binding protein homodimerization activity asialoglycoprotein receptor activity Cellular component integral component of membrane extracellular region integral component of plasma membrane membrane plasma membrane Biological process endocytosis receptor-mediated endocytosis cellular response to extracellular stimulus protein N-linked glycosylation via asparagine viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 432 11889 Ensembl ENSG00000141505 ENSMUSG00000020884 UniProt P07306 P34927 RefSeq (mRNA) NM_001197216 NM_001671 NM_001291131 NM_001291132 NM_009714 RefSeq (protein) NP_001184145 NP_001662 NP_001278060 NP_001278061 NP_033844 Location (UCSC) Chr 17: 7.17 – 7.18 Mb Chr 11: 69.94 – 69.95 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.