B3GAT3

Beta-1,3-Glucuronyltransferase 3 is an enzyme that in humans is encoded by the B3GAT3 gene.^[5][6]

B3GAT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FGG, 1KWS, 3CU0
Identifiers
Aliases	B3GAT3, GLCATI, glcUAT-I, JDSCD, beta-1,3-glucuronyltransferase 3
External IDs	OMIM: 606374; MGI: 1919977; HomoloGene: 56554; GeneCards: B3GAT3; OMA:B3GAT3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.3 Start 62,615,296 bp[1] End 62,622,154 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 8,897,738 bp[2] End 8,904,600 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum anterior pituitary granulocyte right frontal lobe C1 segment anterior cingulate cortex prefrontal cortex nucleus accumbens caudate nucleus amygdala Top expressed in superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex ankle joint cerebellar cortex neural layer of retina granulocyte medial dorsal nucleus lateral geniculate nucleus central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein phosphatase activator activity glucuronosyltransferase activity metal ion binding protein binding galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity Cellular component integral component of membrane Golgi apparatus membrane cis-Golgi network extracellular exosome Golgi membrane Biological process positive regulation of intracellular protein transport glycosaminoglycan metabolic process heparan sulfate proteoglycan biosynthetic process positive regulation of catalytic activity protein glycosylation glycosaminoglycan biosynthetic process chondroitin sulfate proteoglycan biosynthetic process dermatan sulfate proteoglycan biosynthetic process chondroitin sulfate metabolic process carbohydrate metabolic process regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26229 72727 Ensembl ENSG00000149541 ENSMUSG00000071649 UniProt O94766 P58158 RefSeq (mRNA) NM_001288721 NM_001288722 NM_001288723 NM_012200 NM_024256 RefSeq (protein) NP_001275650 NP_001275651 NP_001275652 NP_036332 NP_077218 Location (UCSC) Chr 11: 62.62 – 62.62 Mb Chr 19: 8.9 – 8.9 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans.^[6]