BACH1

Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.^[5][6][7]

BACH1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IHC
Identifiers
Aliases	BACH1, BACH-1, BTBD24, BTB domain and CNC homolog 1
External IDs	OMIM: 602751; MGI: 894680; HomoloGene: 916; GeneCards: BACH1; OMA:BACH1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q21.3 Start 29,194,071 bp[1] End 29,630,751 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C3.3 Start 87,495,833 bp[2] End 87,530,234 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte monocyte Achilles tendon bone marrow cell blood stromal cell of endometrium sperm granulocyte cartilage tissue amniotic fluid Top expressed in epithelium of small intestine intestinal villus Ileal epithelium left lung lobe superior cervical ganglion decidua conjunctival fornix external carotid artery medial ganglionic eminence stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription factor activity ubiquitin-protein transferase activity DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific protein binding heme binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm cytosol Cul3-RING ubiquitin ligase complex nucleus Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II regulation of transcription involved in G1/S transition of mitotic cell cycle transcription, DNA-templated regulation of transcription from RNA polymerase II promoter in response to hypoxia DNA repair positive regulation of transcription by RNA polymerase II regulation of transcription involved in G2/M transition of mitotic cell cycle protein ubiquitination transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 571 12013 Ensembl ENSG00000156273 ENSMUSG00000025612 UniProt O14867 P97302 RefSeq (mRNA) NM_001011545 NM_001186 NM_206866 NM_007520 RefSeq (protein) NP_001177 NP_996749 NP_031546 Location (UCSC) Chr 21: 29.19 – 29.63 Mb Chr 16: 87.5 – 87.53 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. The C-terminus of the protein is a leucine zipper of the bzip_maf family. When this protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. Some exons of this gene overlap with some exons from the GRIK1-AS2 gene, which is transcribed in an opposite orientation to this gene but does not encode a protein.^[7]

See also

• Small Maf (sMaf)
  • Bach1-sMaf heterodimer