BAMBI

This article is about the human gene. For the German media award, see Bambi Award. For other uses, see BAMBI (disambiguation).

BMP and activin membrane-bound inhibitor homolog, also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.^[5][6]

BAMBI
Identifiers
Aliases	BAMBI, NMA, BMP and activin membrane-bound inhibitor, BMP and activin membrane bound inhibitor
External IDs	OMIM: 604444; MGI: 1915260; HomoloGene: 8215; GeneCards: BAMBI; OMA:BAMBI - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p12.1 Start 28,677,510 bp[1] End 28,682,932 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 3,507,923 bp[2] End 3,516,404 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia periodontal fiber left ovary cardiac muscle tissue of right atrium right auricle of heart cartilage tissue right ovary glomerulus adrenal cortex left adrenal gland Top expressed in tooth molar endocardial cushion Meckel's cartilage bones of pectoral girdle clavicle hair follicle upper lip atrioventricular valve body of femur More reference expression data BioGPS n/a
Gene ontology Molecular function type II transforming growth factor beta receptor binding frizzled binding Cellular component cytoplasm integral component of membrane plasma membrane membrane Biological process positive regulation of transcription, DNA-templated positive regulation of protein binding negative regulation of transforming growth factor beta receptor signaling pathway cell migration positive regulation of epithelial to mesenchymal transition positive regulation of cell population proliferation regulation of cell shape positive regulation of canonical Wnt signaling pathway transforming growth factor beta receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25805 68010 Ensembl ENSG00000095739 ENSMUSG00000024232 UniProt Q13145 Q9D0L6 RefSeq (mRNA) NM_012342 NM_026505 RefSeq (protein) NP_036474 NP_080781 Location (UCSC) Chr 10: 28.68 – 28.68 Mb Chr 18: 3.51 – 3.52 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.^[5]