BANP

Protein BANP is a protein that can be found in humans, it is encoded by the BANP gene.^[5][6][7] It is a member of the human gene family, "BEN-domain containing", which includes eight other genes: BEND2, BEND3, BEND4, BEND5, BEND6, BEND7, NACC1 (BEND8), and NACC2 (BEND9). BANP is a protein coding gene that is located in the Nucleoplasm. Its official name is BTG3 associated with nuclear protein. It plays a role in DNA binding, chromatin regulation, repressor, transcription regulation and the cell cycle process.^[8] In recombination BANP protein represses T-cell receptors to control recombination during transcription.^[9] As a tumor suppressor BANP negatively regulates p53 transcription in recombination.^[10] It can be expressed in various tissues in the body including the testis, spleen, and the placenta.^[11]

BANP
Identifiers
Aliases	BANP, BEND1, SMAR1, SMARBP1, BTG3 associated nuclear protein
External IDs	OMIM: 611564; MGI: 1889023; HomoloGene: 9635; GeneCards: BANP; OMA:BANP - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.2 Start 87,949,244 bp[1] End 88,077,318 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 E1|8 70.82 cM Start 122,676,489 bp[2] End 122,755,997 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte blood pancreatic ductal cell middle temporal gyrus amniotic fluid Brodmann area 23 tendon of biceps brachii visceral pleura tibia Top expressed in tail of embryo genital tubercle zygote secondary oocyte Ileal epithelium granulocyte primary oocyte CA3 field morula yolk sac More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding p53 binding protein binding identical protein binding Cellular component nucleus nucleoplasm nuclear body Biological process protein localization to nucleus multicellular organism development positive regulation of transcription, DNA-templated cell cycle regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of protein catabolic process regulation of signal transduction by p53 class mediator chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54971 53325 Ensembl ENSG00000172530 ENSMUSG00000025316 UniProt Q8N9N5 Q8VBU8 RefSeq (mRNA) NM_001173539 NM_001173540 NM_001173541 NM_001173542 NM_001173543 NM_017869 NM_079837 NM_001110100 NM_001285981 NM_001285983 NM_016812 RefSeq (protein) NP_001167010 NP_001167011 NP_001167012 NP_001167013 NP_001167014 NP_060339 NP_524576 NP_001103570 NP_001272910 NP_001272912 NP_058092 Location (UCSC) Chr 16: 87.95 – 88.08 Mb Chr 8: 122.68 – 122.76 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein that binds to matrix attachment regions. The protein functions as a tumor suppressor and cell cycle regulator. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[7]