BASP1

Brain acid soluble protein 1 is a protein that in humans is encoded by the BASP1 gene.^[5][6][7]

BASP1
Identifiers
Aliases	BASP1, CAP-23, CAP23, NAP-22, NAP22, brain abundant membrane attached signal protein 1
External IDs	OMIM: 605940; MGI: 1917600; HomoloGene: 38168; GeneCards: BASP1; OMA:BASP1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p15.1 Start 17,065,598 bp[1] End 17,276,843 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B1 Start 25,363,363 bp[2] End 25,413,850 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in orbitofrontal cortex middle temporal gyrus frontal pole Brodmann area 46 Brodmann area 23 Brodmann area 10 superior frontal gyrus Parietal Lobe postcentral gyrus Occipital Lobe Top expressed in perirhinal cortex CA3 field entorhinal cortex retinal pigment epithelium Amygdala cingulate gyrus prefrontal cortex barrel cortex trigeminal ganglion primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor activity protein domain specific binding protein binding Cellular component cytoplasm vesicle nuclear speck cell projection membrane growth cone plasma membrane cell junction COP9 signalosome extracellular exosome cytoskeleton nucleus Biological process substantia nigra development diaphragm development positive regulation of metanephric ureteric bud development positive regulation of heart growth glomerular visceral epithelial cell differentiation thorax and anterior abdomen determination negative regulation of transcription, DNA-templated gonad development metanephric mesenchyme development mesenchymal to epithelial transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10409 70350 Ensembl ENSG00000176788 ENSMUSG00000045763 UniProt P80723 Q91XV3 RefSeq (mRNA) NM_006317 NM_001271606 NM_027395 RefSeq (protein) NP_001258535 NP_006308 NP_081671 Location (UCSC) Chr 5: 17.07 – 17.28 Mb Chr 15: 25.36 – 25.41 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a membrane bound protein with several transient phosphorylation sites and PEST motifs. Conservation of proteins with PEST sequences among different species supports their functional significance. PEST sequences typically occur in proteins with high turnover rates. Immunological characteristics of this protein are species specific. This protein also undergoes N-terminal myristoylation.^[7]