BAT5

Protein BAT5 is a protein that in humans is encoded by the BAT5 gene.^[5][6][7]

ABHD16A
Identifiers
Aliases	ABHD16A, BAT5, D6S82E, NG26, PP199, abhydrolase domain containing 16A, hBAT5, abhydrolase domain containing 16A, phospholipase, SPG86
External IDs	OMIM: 142620; MGI: 99476; HomoloGene: 10904; GeneCards: ABHD16A; OMA:ABHD16A - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,686,955 bp[1] End 31,703,356 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 18.59 cM Start 35,308,239 bp[2] End 35,321,963 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary right hemisphere of cerebellum granulocyte right lobe of thyroid gland C1 segment left testis right uterine tube right testis ganglionic eminence Top expressed in cerebellar cortex perirhinal cortex lobe of cerebellum muscle of thigh entorhinal cortex choroid plexus of fourth ventricle vestibular membrane of cochlear duct motor neuron cerebellar vermis olfactory epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding hydrolase activity lysophospholipase activity acylglycerol lipase activity phospholipase activity Cellular component membrane integral component of membrane Biological process monoacylglycerol catabolic process prostaglandin catabolic process phosphatidylserine catabolic process lipid metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7920 193742 Ensembl ENSG00000236063 ENSG00000231488 ENSG00000204427 ENSG00000235676 ENSG00000230475 ENSG00000206403 ENSG00000224552 ENSMUSG00000007036 UniProt O95870 Q9Z1Q2 RefSeq (mRNA) NM_001177515 NM_021160 NM_178592 RefSeq (protein) NP_001170986 NP_066983 NP_848707 Location (UCSC) Chr 6: 31.69 – 31.7 Mb Chr 17: 35.31 – 35.32 Mb PubMed search [3] [4]
Wikidata
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A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity.^[7]

Bat5 structure

Amino acid sequence

Cross examination of BAT5 amino acid sequence in humans and mice

The human BAT5 protein (also known as ABHD16A) is 558 amino acid residues long. It was first identified in 1992 in the gene domains of TNF alpha and TNF beta. The BAT5 (ABHD 16A) proteins found in different species have varying lengths.

Structural prediction of human BAT5 (ABHD 16A) protein

BAT5 is highly conserved in human, mice and other mammals.^[8] It is found to be expressed in multiple different tissue cells. According to molecular evolutionary genetic analysis, in comparison of 13 mammalian species, it was denoted that the differences in amino acid sequence length are due to splicing in the post transcriptional processing of mRNA.^[9]

Human chromosome 6 and mouse chromosome 17 BAT5 location

BAT5 gene location

Human Bat5 (ABHD16A) is located on chromosome 6. Mice Bat5 (ABHD 16A) is located between TNF and Heat shock protein near the Ck2b protein kinase gene.^[9]

BAT5 molecular weight

BAT5 molecular weight comparison of humans (H) and mice (m)

BAT5 in humans and mice has been found to be around 63 kDA.

Bat5 implications in recent studies

In previous studies, the connection of malformations in the BAT5 (ABHD 16A) protein had yet to be linked to noticeable human diseases. Yet recent studies show that the BAT5 (ABHD 16A) has been linked to neurological, immune regulation, Kawasaki's disease and coronary artery disease.^[9]

The BAT5 (ABHD 16A) protein has been found to encode a majority of phosphatidylserine (PS) lipase in the brain. PS lipase synthesizes lysophosphatidylserine which is an important signaling lipid that functions in the mammalian central nervous system.^[10] According to a cohort study, relating malformations of the BAT5 (ABHD 16A) protein to human disease, the affected individuals presented with intellectual disability and progressive spasticity of the upper and lower limbs.^[10]