BCAR3

Breast cancer anti-estrogen resistance protein 3 is a protein that in humans is encoded by the BCAR3 gene.^[5][6]

BCAR3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3T6A
Identifiers
Aliases	BCAR3, NSP2, SH2D3B, breast cancer anti-estrogen resistance 3, AND-34, NSP family adaptor protein, BCAR3 adaptor protein, NSP family member, MIG7
External IDs	OMIM: 604704; MGI: 1352501; HomoloGene: 31181; GeneCards: BCAR3; OMA:BCAR3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.1 Start 93,561,741 bp[1] End 93,847,150 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G1 Start 122,087,785 bp[2] End 122,323,840 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland right lung rectum placenta mucosa of transverse colon Skeletal muscle tissue of biceps brachii gastrocnemius muscle sural nerve germinal epithelium subcutaneous adipose tissue Top expressed in primary oocyte zygote secondary oocyte molar jejunum subcutaneous adipose tissue submandibular gland left lobe of liver retinal pigment epithelium intestinal villus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding guanyl-nucleotide exchange factor activity Cellular component intracellular anatomical structure Biological process small GTPase mediated signal transduction lens morphogenesis in camera-type eye signal transduction positive regulation of peptidyl-serine phosphorylation positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8412 29815 Ensembl ENSG00000137936 ENSMUSG00000028121 UniProt O75815 Q9QZK2 RefSeq (mRNA) NM_001261408 NM_001261409 NM_001261410 NM_001308251 NM_003567 NM_013867 NM_001355264 RefSeq (protein) NP_001248337 NP_001248338 NP_001248339 NP_001295180 NP_003558 NP_038895 NP_001342193 Location (UCSC) Chr 1: 93.56 – 93.85 Mb Chr 3: 122.09 – 122.32 Mb PubMed search [3] [4]
Wikidata
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Function

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hallmark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.^[6]