BCAS3

Breast carcinoma amplified sequence 3, also known as BCAS3, is a protein which in humans is encoded by the BCAS3 gene.^[5][6] BCAS3 is a gene that is amplified and overexpressed in breast cancer cells.^[6]

BCAS3
Identifiers
Aliases	BCAS3, GAOB1, MAAB, breast carcinoma amplified sequence 3, microtubule associated cell migration factor, BCAS3 microtubule associated cell migration factor, PHAF2, HEMARS
External IDs	OMIM: 607470; MGI: 2385848; HomoloGene: 9778; GeneCards: BCAS3; OMA:BCAS3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q23.2 Start 60,677,453 bp[1] End 61,392,838 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 85,353,167 bp[2] End 85,826,058 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon sural nerve right uterine tube bone marrow cells Achilles tendon prefrontal cortex testicle olfactory zone of nasal mucosa right coronary artery popliteal artery Top expressed in seminal vesicula morula muscle of thigh neural layer of retina superior frontal gyrus dentate gyrus of hippocampal formation granule cell genital tubercle blastocyst lip yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone binding chromatin binding acetyltransferase activator activity beta-tubulin binding histone acetyltransferase binding transcription factor binding protein binding Cellular component intermediate filament cytoskeleton nucleolus cell periphery cell leading edge cytoplasmic microtubule cytoskeleton nucleus cytoplasm Biological process angiogenesis cellular response to estrogen stimulus positive regulation of endothelial cell migration positive regulation of GTPase activity positive regulation of intracellular protein transport transcription, DNA-templated positive regulation of actin cytoskeleton reorganization microtubule organizing center organization negative regulation of focal adhesion assembly response to starvation activation of GTPase activity Golgi organization regulation of establishment of cell polarity tube formation regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of GTPase activity positive regulation of catalytic activity positive regulation of filopodium assembly vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54828 192197 Ensembl ENSG00000141376 ENSMUSG00000059439 UniProt Q9H6U6 Q8CCN5 RefSeq (mRNA) NM_001099432 NM_017679 NM_001320470 NM_001330413 NM_001330414 NM_001353144 NM_001353145 NM_001353146 NM_001166642 NM_001166643 NM_138681 RefSeq (protein) NP_001092902 NP_001307399 NP_001317342 NP_001317343 NP_060149 NP_001340073 NP_001340074 NP_001340075 NP_001160114 NP_001160115 NP_619622 Location (UCSC) Chr 17: 60.68 – 61.39 Mb Chr 11: 85.35 – 85.83 Mb PubMed search [3] [4]
Wikidata
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Function

The BCAS3 gene is regulated by estrogen receptor alpha (ER-α).^[7] The PELP1 protein acts as a transcriptional coactivator of estrogen receptor induced BCAS3 gene expression. In addition BCAS3 possesses histone acetyltransferase activity and itself appears to act as a coactivator of ER-α.^{[8][better source needed]} Furthermore, BCAS3 requires PELP1 to function as a coactivator in ER-α. Hence BCAS3 apparently is involved in a positive feedback loop leading to ER-α mediated signal amplification.^{[8][better source needed]}