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BCCIP
Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
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BRCA2 and CDKN1A-interacting protein is a protein that is encoded by the BCCIP gene in humans.[5][6][7]
This gene product was isolated based on its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene.[7]
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Interactions
BCCIP has been shown to interact with BRCA2,[5] P21,[6] and PTPmu (PTPRM)[8]
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