Top Qs
Timeline
Chat
Perspective

BCCIP

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

BCCIP
Remove ads

BRCA2 and CDKN1A-interacting protein is a protein that is encoded by the BCCIP gene in humans.[5][6][7]

Quick Facts Identifiers, Aliases ...

This gene product was isolated based on its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene.[7]

Remove ads

Interactions

BCCIP has been shown to interact with BRCA2,[5] P21,[6] and PTPmu (PTPRM)[8]

References

Further reading

Loading related searches...

Wikiwand - on

Seamless Wikipedia browsing. On steroids.

Remove ads