BCL2L14

Apoptosis facilitator Bcl-2-like protein 14 is a protein that in humans is encoded by the BCL2L14 gene.^[5][6]

BCL2L14
Identifiers
Aliases	BCL2L14, BCLG, BCL2 like 14
External IDs	OMIM: 606126; MGI: 1914063; HomoloGene: 49840; GeneCards: BCL2L14; OMA:BCL2L14 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.2 Start 12,049,844 bp[1] End 12,211,084 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G1 Start 134,373,281 bp[2] End 134,415,699 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum duodenum left testis right testis mucosa of transverse colon testicle epithelium of colon body of pancreas gonad appendix Top expressed in seminiferous tubule spermatid transitional epithelium of urinary bladder submandibular gland crypt of lieberkuhn of small intestine duodenum mucous cell of stomach left colon pyloric antrum epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase binding Cellular component intracellular organelle membrane endomembrane system cytosol cytoplasm Biological process positive regulation of extrinsic apoptotic signaling pathway apoptotic process regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79370 66813 Ensembl ENSG00000281449 ENSG00000121380 ENSMUSG00000030200 UniProt Q9BZR8 Q9CPT0 RefSeq (mRNA) NM_030766 NM_138722 NM_138723 NM_138724 NM_001370268 NM_001370269 NM_025778 NM_001355686 RefSeq (protein) NP_110393 NP_620048 NP_620049 NP_001357197 NP_001357198 NP_080054 NP_001342615 Location (UCSC) Chr 12: 12.05 – 12.21 Mb Chr 6: 134.37 – 134.42 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Four alternatively spliced transcript variants, which encode three distinct isoforms, have been reported for this gene.^[6]