BCL7A

B-cell CLL/lymphoma 7 protein family member A is a protein that in humans is encoded by the BCL7A gene located in the chromosome 12 (Cytogenetic band: 12q24.31).^[5]

BCL7A
Identifiers
Aliases	BCL7A, BCL7, B-cell CLL/lymphoma 7A, BCL tumor suppressor 7A, BAF complex component, BAF chromatin remodeling complex subunit SMARCJ1
External IDs	OMIM: 601406; MGI: 1924295; HomoloGene: 10869; GeneCards: BCL7A; OMA:BCL7A - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 122,019,422 bp[1] End 122,062,044 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 123,481,897 bp[2] End 123,513,055 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone prefrontal cortex superior frontal gyrus Brodmann area 9 cerebellum cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum primary visual cortex Top expressed in hand ganglionic eminence superior cervical ganglion utricle ventricular zone olfactory system olfactory epithelium prefrontal cortex piriform cortex primary motor cortex More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding molecular function Cellular component cellular component Biological process negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 605 77045 Ensembl ENSG00000282873 ENSG00000110987 ENSMUSG00000029438 UniProt Q4VC05 Q9CXE2 RefSeq (mRNA) NM_020993 NM_001024808 NM_029850 RefSeq (protein) NP_001019979 NP_066273 NP_084126 Location (UCSC) Chr 12: 122.02 – 122.06 Mb Chr 5: 123.48 – 123.51 Mb PubMed search [3] [4]
Wikidata
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Function

This gene codifies for a protein that belongs to the SWI/SNF chromatin remodelling complex, a complex that is able to modify the interations between DNA and histones using the energy of the ATP hydrolysis. It has found recurrently mutated in lymphomas^[6] and silenced by promoter hypermetylation in haematological malignancies.^[7][8]

See also

• B-cell lymphoma