BDP1

Transcription factor TFIIIB component B″ homolog also known as TFIIIB150 is a protein that in humans is encoded by the BDP1 gene.^[5][6][7]

BDP1
Identifiers
Aliases	BDP1, HSA238520, TAF3B1, TFC5, TFIIIB150, TFIIIB90, TFNR, B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB, DFNB112, TFIIIB''
External IDs	OMIM: 607012; MGI: 1347077; HomoloGene: 34582; GeneCards: BDP1; OMA:BDP1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q13.2 Start 71,455,651 bp[1] End 71,567,820 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 D1|13 52.92 cM Start 100,017,994 bp[2] End 100,104,070 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon epithelium of colon corpus callosum right uterine tube testicle tonsil bone marrow cells ventricular zone endometrium Top expressed in superior cervical ganglion hand otolith organ utricle cumulus cell tail of embryo primitive streak medullary collecting duct condyle fossa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding TFIIIC-class transcription factor complex binding RNA polymerase III general transcription initiation factor activity Cellular component nucleus transcription factor TFIIIB complex nucleoplasm Biological process regulation of transcription by RNA polymerase III regulation of transcription, DNA-templated transcription, DNA-templated RNA polymerase III preinitiation complex assembly transcription by RNA polymerase III Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55814 544971 Ensembl ENSG00000274803 ENSG00000273873 ENSG00000145734 ENSMUSG00000049658 UniProt A6H8Y1 H7C5U4 Q571C7 RefSeq (mRNA) NM_018429 NM_001081061 RefSeq (protein) NP_060899 NP_001074530 Location (UCSC) Chr 5: 71.46 – 71.57 Mb Chr 13: 100.02 – 100.1 Mb PubMed search [3] [4]
Wikidata
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Function

TFIIIB150 is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase 2 during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription.^[7]