BHLHB2

Class E basic helix-loop-helix protein 40 is a protein that in humans is encoded by the BHLHE40 gene.^[5][6][7][8]

BHLHE40
Identifiers
Aliases	BHLHE40, BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14, basic helix-loop-helix family member e40, Clast5, SHARP2
External IDs	OMIM: 604256; MGI: 1097714; HomoloGene: 2722; GeneCards: BHLHE40; OMA:BHLHE40 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p26.1 Start 4,979,437 bp[1] End 4,985,323 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 E2 Start 108,637,590 bp[2] End 108,643,886 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein vena cava beta cell mucosa of pharynx synovial joint pericardium tail of epididymis gastric mucosa mucosa of paranasal sinus human penis Top expressed in ankle decidua plantaris muscle extensor digitorum longus muscle cervix iris left lobe of liver tibialis anterior muscle ciliary body triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein dimerization activity protein homodimerization activity MRF binding transcription corepressor activity protein domain specific binding DNA-binding transcription factor activity DNA-binding transcription repressor activity, RNA polymerase II-specific bHLH transcription factor binding E-box binding protein binding protein heterodimerization activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription factor binding sequence-specific DNA binding sequence-specific double-stranded DNA binding Cellular component cytoplasm nucleus nuclear body Biological process regulation of transcription, DNA-templated response to light stimulus rhythmic process negative regulation of transcription by RNA polymerase II circadian regulation of gene expression transcription, DNA-templated negative regulation of DNA-binding transcription factor activity negative regulation of transcription, DNA-templated entrainment of circadian clock by photoperiod circadian rhythm somitogenesis Notch signaling pathway cell differentiation regulation of neurogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8553 20893 Ensembl ENSG00000134107 ENSMUSG00000030103 UniProt O14503 O35185 RefSeq (mRNA) NM_003670 NM_011498 RefSeq (protein) NP_003661 NP_035628 Location (UCSC) Chr 3: 4.98 – 4.99 Mb Chr 6: 108.64 – 108.64 Mb PubMed search [3] [4]
Wikidata
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Function

DEC1 encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. Differentiated embryo chondrocyte expressed gene 1 is believed to be involved in the control of cell differentiation.^[8]