BIRC7

Baculoviral IAP repeat-containing protein 7 is a protein that in humans is encoded by the BIRC7 gene.^[5][6][7]

BIRC7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OXN, 1OXQ, 1OY7, 1TW6, 2I3H, 2I3I, 3F7G, 3F7H, 3F7I, 3GT9, 3GTA, 3UW5, 4AUQ
Identifiers
Aliases	BIRC7, KIAP, LIVIN, ML-IAP, MLIAP, RNF50, baculoviral IAP repeat containing 7
External IDs	OMIM: 605737; MGI: 2676458; HomoloGene: 51405; GeneCards: BIRC7; OMA:BIRC7 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 63,235,883 bp[1] End 63,240,495 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H4 Start 180,570,816 bp[2] End 180,575,803 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial nerve sural nerve placenta right adrenal cortex right lung gonad skin of leg skin of abdomen lymph node C1 segment Top expressed in lens epithelium of lens set of lens fibers ankle embryo dentate gyrus dentate gyrus of hippocampal formation granule cell cerebellar cortex primary visual cortex neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity cysteine-type endopeptidase inhibitor activity metal ion binding ubiquitin-protein transferase activity protein binding enzyme binding transferase activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process ubiquitin protein ligase activity Cellular component cytoplasm Golgi apparatus nucleus microtubule organizing center cytosol Biological process negative regulation of peptidase activity inhibition of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of apoptotic process regulation of natural killer cell apoptotic process mitotic spindle assembly regulation of cell population proliferation regulation of signal transduction protein ubiquitination apoptotic process positive regulation of protein ubiquitination negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79444 329581 Ensembl ENSG00000101197 ENSMUSG00000038840 UniProt Q96CA5 A2AWP0 RefSeq (mRNA) NM_139317 NM_022161 NM_001163247 RefSeq (protein) NP_071444 NP_647478 NP_001156719 Location (UCSC) Chr 20: 63.24 – 63.24 Mb Chr 2: 180.57 – 180.58 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.^[7] In melanoma, BIRC7 gene expression is regulated by the Microphthalmia-associated transcription factor.^[8][9]