BPY2

Testis-specific basic protein Y 2 also known as basic charge, Y-linked 2 is a protein that in humans is encoded by the BPY2 gene which resides on the Y chromosome.^[3]

BPY2
Identifiers
Aliases	BPY2, BPY2A, VCY2, VCY2A, basic charge, Y-linked, 2, basic charge Y-linked 2
External IDs	OMIM: 400013; GeneCards: BPY2; OMA:BPY2 - orthologs
Gene location (Human) Chr. Y chromosome (human)[1] Band Yq11.223 Start 22,973,819 bp[1] End 23,005,465 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis gallbladder right lobe of liver human kidney skin of abdomen human musculoskeletal system skeletal muscle muscle of leg gastrocnemius muscle n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding HECT domain binding Cellular component nucleus Biological process spermatogenesis single fertilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9083 n/a Ensembl ENSG00000183753 n/a UniProt O14599 n/a RefSeq (mRNA) NM_004678 n/a RefSeq (protein) NP_001002760 n/a Location (UCSC) Chr Y: 22.97 – 23.01 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. The encoded protein interacts with ubiquitin protein ligase E3A and may be involved in male germ cell development and male infertility. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the copy outside of the palindromic region.^[4]