BRAP

BRCA1 associated protein is a protein that in humans is encoded by the BRAP gene. ^[5]

BRAP
Identifiers
Aliases	BRAP, BRAP2, IMP, RNF52, BRCA1 associated protein
External IDs	OMIM: 604986; MGI: 1919649; HomoloGene: 4926; GeneCards: BRAP; OMA:BRAP - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.12 Start 111,642,146 bp[1] End 111,685,956 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 121,798,626 bp[2] End 121,825,319 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis secondary oocyte sperm buccal mucosa cell gonad Achilles tendon gastrocnemius muscle islet of Langerhans testicle Top expressed in spermatid spermatocyte seminiferous tubule right kidney zygote lumbar spinal ganglion secondary oocyte lip dentate gyrus of hippocampal formation granule cell left lobe of liver More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin protein ligase activity zinc ion binding metal ion binding ubiquitin-protein transferase activity protein binding nuclear localization sequence binding identical protein binding nucleic acid binding transferase activity Cellular component cytoplasm nuclear membrane ubiquitin ligase complex cytosol Biological process MAPK cascade protein ubiquitination negative regulation of signal transduction Ras protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8315 72399 Ensembl ENSG00000089234 ENSMUSG00000029458 UniProt Q7Z569 Q99MP8 RefSeq (mRNA) NM_006768 NM_001289543 NM_001289544 NM_028227 RefSeq (protein) NP_006759 NP_001276472 NP_001276473 NP_082503 Location (UCSC) Chr 12: 111.64 – 111.69 Mb Chr 5: 121.8 – 121.83 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008].