BRCT domain

BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins. It is named after the C-terminal domain of BRCA1, a DNA-repair protein that serves as a marker of breast cancer susceptibility.

BRCA1 C Terminus (BRCT) domain
Structure of an XRCC1 BRCT domain.[1]
Identifiers
Symbol	BRCT
Pfam	PF00533
InterPro	IPR001357
SCOP2	1cdz / SCOPe / SUPFAM
CDD	cd00027
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary PDB 2azmB:1906-1957 2adoB:1906-1957 2etxA:1906-1957 1kzyC:1795-1835 1l0bA:1589-1669 1t2vC:1646-1723 1n5oX:1646-1723 1t2uA:1646-1723 1jnxX:1646-1723 1t15A:1646-1723 1t29A:1646-1723 1y98A:1646-1723 2couA:91-166 1l7bA:589-664 2cokA:385-463 1wf6A:354-431 1ik9C:681-717 1cdzA:538-616 1oqaA:1756-1842 2coeA:27-111

The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage,^[2] for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain.^[3]

Examples

Human proteins containing this domain include:

• BARD1; BRCA1
• CTDP1; TDT or DNTT
• ECT2
• LIG4
• MCPH1; MDC1
• NBN
• PARP1; PARP4; PAXIP1; PES1
• REV1; RFC1; TOPBP1; TP53BP1; XRCC1