CTDP1

RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.^[5][6][7]

CTDP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J2X, 1ONV, 2K7L
Identifiers
Aliases	CTDP1, CCFDN, FCP1, CTD phosphatase subunit 1
External IDs	OMIM: 604927; MGI: 1926953; HomoloGene: 31254; GeneCards: CTDP1; OMA:CTDP1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q23 Start 79,679,803 bp[1] End 79,754,503 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 E3|18 53.48 cM Start 80,451,174 bp[2] End 80,512,910 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis skin of leg oocyte granulocyte blood mucosa of transverse colon skin of abdomen secondary oocyte monocyte Top expressed in spermatid otic vesicle epiblast fetal liver hematopoietic progenitor cell hair follicle seminiferous tubule Gonadal ridge primitive streak somite Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II CTD heptapeptide repeat phosphatase activity protein binding hydrolase activity phosphoprotein phosphatase activity TFIIF-class transcription factor complex binding Tat protein binding Cellular component cytoplasm centrosome spindle pole RNA polymerase II, holoenzyme spindle microtubule organizing center midbody spindle midzone cytoskeleton nucleus nucleoplasm intracellular membrane-bounded organelle protein-containing complex actin cytoskeleton nuclear speck Biological process transcription elongation from RNA polymerase II promoter protein dephosphorylation exit from mitosis transcription by RNA polymerase II cell division negative regulation of cell growth involved in cardiac muscle cell development dephosphorylation of RNA polymerase II C-terminal domain cell cycle positive regulation by host of viral transcription positive regulation of viral transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9150 67655 Ensembl ENSG00000282752 ENSG00000060069 ENSMUSG00000033323 UniProt Q9Y5B0 Q7TSG2 RefSeq (mRNA) NM_001202504 NM_004715 NM_048368 NM_001318511 NM_026295 RefSeq (protein) NP_001189433 NP_001305440 NP_004706 NP_430255 NP_080571 Location (UCSC) Chr 18: 79.68 – 79.75 Mb Chr 18: 80.45 – 80.51 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein which interacts with the carboxy-terminus of transcription initiation factor TFIIF, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. The protein may also represent a component of an RNA polymerase II holoenzyme complex. Alternative splicing of this gene results in two transcript variants encoding 2 different isoforms.^[7]

Interactions

CTDP1 has been shown to interact with WD repeat-containing protein 77,^[8] GTF2F1^[6] and POLR2A.^[9]