BRF1 (gene)

Transcription factor IIIB 90 kDa subunit is a protein that in humans is encoded by the BRF1 gene.^[5][6][7]

BRF1
Identifiers
Aliases	BRF1, BRF, BRF-1, GTF3B, HEL-S-76p, TAF3B2, TAF3C, TAFIII90, TF3B90, TFIIIB90, hBRF, CFDS, RNA polymerase III transcription initiation factor 90 kDa subunit, RNA polymerase III transcription initiation factor subunit, BRF1 RNA polymerase III transcription initiation factor subunit
External IDs	OMIM: 604902; MGI: 1919558; HomoloGene: 1161; GeneCards: BRF1; OMA:BRF1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.33 Start 105,209,286 bp[1] End 105,315,589 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 F1 Start 112,923,705 bp[2] End 112,964,324 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve right uterine tube right hemisphere of cerebellum C1 segment anterior pituitary right frontal lobe ventricular zone ganglionic eminence apex of heart granulocyte Top expressed in interventricular septum neural layer of retina lens thymus granulocyte lip otolith organ utricle spermatocyte hand More reference expression data BioGPS More reference expression data
Gene ontology Molecular function TBP-class protein binding metal ion binding RNA polymerase III general transcription initiation factor activity RNA polymerase III type 3 promoter sequence-specific DNA binding transcription factor binding protein binding translation initiation factor activity Cellular component transcription factor TFIIIB complex nucleus nucleoplasm Biological process rRNA transcription tRNA transcription regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase III transcription by RNA polymerase III transcription initiation from RNA polymerase III promoter transcription preinitiation complex assembly DNA-templated transcription, initiation RNA polymerase III preinitiation complex assembly regulation of transcription by RNA polymerase III translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2972 72308 Ensembl ENSG00000185024 ENSMUSG00000011158 UniProt Q92994 Q8CFK2 RefSeq (mRNA) NM_001242786 NM_001242787 NM_001242788 NM_001242789 NM_001242790 NM_001519 NM_145685 NM_145696 NM_028193 RefSeq (protein) NP_001229715 NP_001229716 NP_001229717 NP_001229718 NP_001229719 NP_001510 NP_663718 NP_663718.1 NP_082469 Location (UCSC) Chr 14: 105.21 – 105.32 Mb Chr 12: 112.92 – 112.96 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Three alternatively spliced variants encoding three different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. A transcript encoding a fourth isoform has not yet been completely characterized.^[7]

Interactions

BRF1 (gene) has been shown to interact with:

• RB1,^[8][9]
• RBL1,^[8]
• RBL2,^[8] and
• TBP^[5][10]